Cargando…
Phosphorylation of Ku70 subunit by cell cycle kinases modulates the replication related function of Ku heterodimer
The Ku protein, a heterodimer of Ku70 and Ku80, binds to chromosomal replication origins maximally at G1-phase and plays an essential role in assembly of origin recognition complex. However, the mechanism regulating such a critical periodic activity of Ku remained unknown. Here, we establish human K...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2016
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027504/ https://www.ncbi.nlm.nih.gov/pubmed/27402161 http://dx.doi.org/10.1093/nar/gkw622 |