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ATP from synaptic terminals and astrocytes regulates NMDA receptors and synaptic plasticity through PSD-95 multi-protein complex

Recent studies highlighted the importance of astrocyte-secreted molecules, such as ATP, for the slow modulation of synaptic transmission in central neurones. Biophysical mechanisms underlying the impact of gliotransmitters on the strength of individual synapse remain, however, unclear. Here we show...

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Detalles Bibliográficos
Autores principales: Lalo, U., Palygin, O., Verkhratsky, A., Grant, S. G. N., Pankratov, Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027525/
https://www.ncbi.nlm.nih.gov/pubmed/27640997
http://dx.doi.org/10.1038/srep33609