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Human CB1 Receptor Isoforms, present in Hepatocytes and β-cells, are Involved in Regulating Metabolism
Therapeutics aimed at blocking the cannabinoid 1 (CB1) receptor for treatment of obesity resulted in significant improvements in liver function, glucose uptake and pancreatic β-cell function independent of weight loss or CB1 receptor blockade in the brain, suggesting that peripherally-acting only CB...
Autores principales: | González-Mariscal, Isabel, Krzysik-Walker, Susan M., Doyle, Máire E., Liu, Qing-Rong, Cimbro, Raffaello, Santa-Cruz Calvo, Sara, Ghosh, Soumita, Cieśla, Łukasz, Moaddel, Ruin, Carlson, Olga D., Witek, Rafal P., O’Connell, Jennifer F., Egan, Josephine M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027555/ https://www.ncbi.nlm.nih.gov/pubmed/27641999 http://dx.doi.org/10.1038/srep33302 |
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