Functional Recovery of AQP2 Recessive Mutations Through Hetero-Oligomerization with Wild-Type Counterpart

Aquaporin-2 (AQP2) is a homotetrameric water channel responsible for the final water reuptake in the kidney. Mutations in the protein induce nephrogenic diabetes insipidus (NDI), which challenges the water balance by producing large urinary volumes. Although recessive AQP2 mutations are believed to...

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Detalles Bibliográficos
Autores principales: El Tarazi, Abdulah, Lussier, Yoann, Da Cal, Sandra, Bissonnette, Pierre, Bichet, Daniel G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027563/
https://www.ncbi.nlm.nih.gov/pubmed/27641679
http://dx.doi.org/10.1038/srep33298

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027563/
https://www.ncbi.nlm.nih.gov/pubmed/27641679
http://dx.doi.org/10.1038/srep33298

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