β-Hairpin of Islet Amyloid Polypeptide Bound to an Aggregation Inhibitor

In type 2 diabetes, the formation of islet amyloid consisting of islet amyloid polypeptide (IAPP) is associated with reduction in β-cell mass and contributes to the failure of islet cell transplantation. Rational design of inhibitors of IAPP amyloid formation has therapeutic potential, but is hamper...

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Detalles Bibliográficos
Autores principales: Mirecka, Ewa A., Feuerstein, Sophie, Gremer, Lothar, Schröder, Gunnar F., Stoldt, Matthias, Willbold, Dieter, Hoyer, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027568/
https://www.ncbi.nlm.nih.gov/pubmed/27641459
http://dx.doi.org/10.1038/srep33474

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027568/
https://www.ncbi.nlm.nih.gov/pubmed/27641459
http://dx.doi.org/10.1038/srep33474

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