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Single-Molecule Imaging Reveals the Activation Dynamics of Intracellular Protein Smad3 on Cell Membrane

Smad3 is an intracellular protein that plays a key role in propagating transforming growth factor β (TGF-β) signals from cell membrane to nucleus. However whether the transient process of Smad3 activation occurs on cell membrane and how it is regulated remains elusive. Using advanced live-cell singl...

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Detalles Bibliográficos
Autores principales: Li, Nan, Yang, Yong, He, Kangmin, Zhang, Fayun, Zhao, Libo, Zhou, Wei, Yuan, Jinghe, Liang, Wei, Fang, Xiaohong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027577/
https://www.ncbi.nlm.nih.gov/pubmed/27641076
http://dx.doi.org/10.1038/srep33469