TSPO ligands stimulate ZnPPIX transport and ROS accumulation leading to the inhibition of P. falciparum growth in human blood

After invading red blood cells (RBCs), Plasmodium falciparum (Pf) can export its own proteins to the host membrane and activate endogenous channels that are present in the membrane of RBCs. This transport pathway involves the Voltage Dependent Anion Channel (VDAC). Moreover, ligands of the VDAC part...

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Detalles Bibliográficos
Autores principales: Marginedas-Freixa, I., Hattab, C., Bouyer, G., Halle, F., Chene, A., Lefevre, S. D., Cambot, M., Cueff, A., Schmitt, M., Gamain, B., Lacapere, J. J., Egee, S., Bihel, F., Le Van Kim, C., Ostuni, M. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027585/
https://www.ncbi.nlm.nih.gov/pubmed/27641616
http://dx.doi.org/10.1038/srep33516

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027585/
https://www.ncbi.nlm.nih.gov/pubmed/27641616
http://dx.doi.org/10.1038/srep33516

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