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PD-1 pathway-mediated regulation of islet-specific CD4(+) T cell subsets in autoimmune diabetes
Type 1 diabetes (T1D) is a CD4(+) T cell-driven autoimmune disease resulting from the destruction of insulin-producing pancreatic beta cells. Clinical evidence and studies in non-obese diabetic (NOD) mice suggest that insulin is a major autoantigen. With this in mind, we developed insulin B(10-23):I...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027981/ https://www.ncbi.nlm.nih.gov/pubmed/27656680 http://dx.doi.org/10.14800/ie.1164 |