A triazole derivative elicits autophagic clearance of polyglutamine aggregation in neuronal cells

Trinucleotide CAG repeat expansion in the coding region of genes has a propensity to form polyglutamine (polyQ) aggregates that contribute to neuronal disorders. Strategies in elevating autophagy to disintegrate the insoluble aggregates without injuring cells have become a major goal for therapy. In...

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Detalles Bibliográficos
Autores principales: Hsieh, Chang Heng, Lee, Li-Ching, Leong, Wai-Yin, Yang, Tsai-Chen, Yao, Ching-Fa, Fang, Kang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028077/
https://www.ncbi.nlm.nih.gov/pubmed/27695292
http://dx.doi.org/10.2147/DDDT.S111903

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028077/
https://www.ncbi.nlm.nih.gov/pubmed/27695292
http://dx.doi.org/10.2147/DDDT.S111903

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