Application of physiologically based pharmacokinetic modeling in predicting drug–drug interactions for sarpogrelate hydrochloride in humans

BACKGROUND: Evaluating the potential risk of metabolic drug–drug interactions (DDIs) is clinically important. OBJECTIVE: To develop a physiologically based pharmacokinetic (PBPK) model for sarpogrelate hydrochloride and its active metabolite, (R,S)-1-{2-[2-(3-methoxyphenyl)ethyl]-phenoxy}-3-(dimethy...

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Detalles Bibliográficos
Autores principales: Min, Jee Sun, Kim, Doyun, Park, Jung Bae, Heo, Hyunjin, Bae, Soo Hyeon, Seo, Jae Hong, Oh, Euichaul, Bae, Soo Kyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028085/
https://www.ncbi.nlm.nih.gov/pubmed/27695293
http://dx.doi.org/10.2147/DDDT.S109141

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028085/
https://www.ncbi.nlm.nih.gov/pubmed/27695293
http://dx.doi.org/10.2147/DDDT.S109141

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