Conditional deletion of WT1 in the septum transversum mesenchyme causes congenital diaphragmatic hernia in mice

Congenital diaphragmatic hernia (CDH) is a severe birth defect. Wt1-null mouse embryos develop CDH but the mechanisms regulated by WT1 are unknown. We have generated a murine model with conditional deletion of WT1 in the lateral plate mesoderm, using the G2 enhancer of the Gata4 gene as a driver. 80...

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Detalles Bibliográficos
Autores principales: Carmona, Rita, Cañete, Ana, Cano, Elena, Ariza, Laura, Rojas, Anabel, Muñoz-Chápuli, Ramon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Developmental Biology and Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028188/
https://www.ncbi.nlm.nih.gov/pubmed/27642710
http://dx.doi.org/10.7554/eLife.16009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028188/
https://www.ncbi.nlm.nih.gov/pubmed/27642710
http://dx.doi.org/10.7554/eLife.16009

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