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Avoidance of stochastic RNA interactions can be harnessed to control protein expression levels in bacteria and archaea

A critical assumption of gene expression analysis is that mRNA abundances broadly correlate with protein abundance, but these two are often imperfectly correlated. Some of the discrepancy can be accounted for by two important mRNA features: codon usage and mRNA secondary structure. We present a new...

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Detalles Bibliográficos
Autores principales: Umu, Sinan Uğur, Poole, Anthony M, Dobson, Renwick CJ, Gardner, Paul P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028192/
https://www.ncbi.nlm.nih.gov/pubmed/27642845
http://dx.doi.org/10.7554/eLife.13479