Natural flavonoids silymarin and quercetin improve the brain distribution of co-administered P-gp substrate drugs

P-glycoprotein (P-gp), a well known efflux transporter in the blood brain barrier inhibits the uptake of substrate drugs into brain. The main aim of this study is to evaluate the effect of natural product based P-gp inhibitors on brain penetration of various CNS drugs which are P-gp substrates. In t...

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Detalles Bibliográficos
Autores principales: Ravikumar Reddy, D., Khurana, Amit, Bale, Swarna, Ravirala, Ramu, Samba Siva Reddy, V., Mohankumar, M., Godugu, Chandraiah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028351/
https://www.ncbi.nlm.nih.gov/pubmed/27652191
http://dx.doi.org/10.1186/s40064-016-3267-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028351/
https://www.ncbi.nlm.nih.gov/pubmed/27652191
http://dx.doi.org/10.1186/s40064-016-3267-1

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