Cargando…
Natural flavonoids silymarin and quercetin improve the brain distribution of co-administered P-gp substrate drugs
P-glycoprotein (P-gp), a well known efflux transporter in the blood brain barrier inhibits the uptake of substrate drugs into brain. The main aim of this study is to evaluate the effect of natural product based P-gp inhibitors on brain penetration of various CNS drugs which are P-gp substrates. In t...
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer International Publishing
2016
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028351/ https://www.ncbi.nlm.nih.gov/pubmed/27652191 http://dx.doi.org/10.1186/s40064-016-3267-1 |