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Activation of ATP-sensitive potassium channels enhances DMT1-mediated iron uptake in SK-N-SH cells in vitro

Iron importer divalent metal transporter 1 (DMT1) plays a crucial role in the nigal iron accumulation in Parkinson’s disease (PD). Membrane hyperpolarization is one of the factors that could affect its iron transport function. Besides iron, selective activation of the ATP-sensitive potassium (K(ATP)...

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Detalles Bibliográficos
Autores principales: Du, Xixun, Xu, Huamin, Shi, Limin, Jiang, Zhifeng, Song, Ning, Jiang, Hong, Xie, Junxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028757/
https://www.ncbi.nlm.nih.gov/pubmed/27646472
http://dx.doi.org/10.1038/srep33674