Increased PKCα activity by Rack1 overexpression is responsible for chemotherapy resistance in T-cell acute lymphoblastic leukemia-derived cell line

Chemoresistant mechanisms in T-cell acute lymphoblastic leukemia (T-ALL) patients are not clarified. The apoptotic signaling mediated by receptor of activated C kinase 1 (Rack1), protein kinase C (PKC) and FEM1 homolog b (FEM1b) was investigated in two T-ALL-derived cell lines (Jurkat and CCRF-CEM)...

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Detalles Bibliográficos
Autores principales: Lei, Jie, Li, Qi, Gao, Ying, Zhao, Lei, Liu, Yanbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028770/
https://www.ncbi.nlm.nih.gov/pubmed/27644318
http://dx.doi.org/10.1038/srep33717

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028770/
https://www.ncbi.nlm.nih.gov/pubmed/27644318
http://dx.doi.org/10.1038/srep33717

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