Structural basis for disruption of claudin assembly in tight junctions by an enterotoxin

The food-poisoning bacterium Clostridium perfringens produces an enterotoxin (~35 kDa) that specifically targets human claudin-4, among the 26 human claudin proteins, and causes diarrhea by fluid accumulation in the intestinal cavity. The C-terminal domain of the Clostridium perfringens enterotoxin...

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Detalles Bibliográficos
Autores principales: Shinoda, Takehiro, Shinya, Naoko, Ito, Kaori, Ohsawa, Noboru, Terada, Takaho, Hirata, Kunio, Kawano, Yoshiaki, Yamamoto, Masaki, Kimura-Someya, Tomomi, Yokoyama, Shigeyuki, Shirouzu, Mikako
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028891/
https://www.ncbi.nlm.nih.gov/pubmed/27647526
http://dx.doi.org/10.1038/srep33632

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028891/
https://www.ncbi.nlm.nih.gov/pubmed/27647526
http://dx.doi.org/10.1038/srep33632

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