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Structural basis for disruption of claudin assembly in tight junctions by an enterotoxin
The food-poisoning bacterium Clostridium perfringens produces an enterotoxin (~35 kDa) that specifically targets human claudin-4, among the 26 human claudin proteins, and causes diarrhea by fluid accumulation in the intestinal cavity. The C-terminal domain of the Clostridium perfringens enterotoxin...
Autores principales: | Shinoda, Takehiro, Shinya, Naoko, Ito, Kaori, Ohsawa, Noboru, Terada, Takaho, Hirata, Kunio, Kawano, Yoshiaki, Yamamoto, Masaki, Kimura-Someya, Tomomi, Yokoyama, Shigeyuki, Shirouzu, Mikako |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028891/ https://www.ncbi.nlm.nih.gov/pubmed/27647526 http://dx.doi.org/10.1038/srep33632 |
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