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Recent advances in animal and human pluripotent stem cell modeling of cardiac laminopathy

Laminopathy is a disease closely related to deficiency of the nuclear matrix protein lamin A/C or failure in prelamin A processing, and leads to accumulation of the misfold protein causing progeria. The resultant disrupted lamin function is highly associated with abnormal nuclear architecture, cell...

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Detalles Bibliográficos
Autores principales: Lee, Yee-Ki, Jiang, Yu, Ran, Xin-Ru, Lau, Yee-Man, Ng, Kwong-Man, Lai, Wing-Hon Kevin, Siu, Chung-Wah, Tse, Hung-Fat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029055/
https://www.ncbi.nlm.nih.gov/pubmed/27649756
http://dx.doi.org/10.1186/s13287-016-0401-5