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Characterization of the tRNA ligases of pathogenic fungi Aspergillus fumigatus and Coccidioides immitis
Yeast tRNA ligase (Trl1) is an essential trifunctional enzyme that repairs RNA breaks with 2′,3′-cyclic-PO(4) and 5′-OH ends. Trl1 is composed of C-terminal cyclic phosphodiesterase and central polynucleotide kinase domains that heal the broken ends to generate the 3′-OH, 2′-PO(4), and 5′-PO(4) term...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory Press
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029449/ https://www.ncbi.nlm.nih.gov/pubmed/27492257 http://dx.doi.org/10.1261/rna.057455.116 |