Epidermal Nbn deletion causes premature hair loss and a phenotype resembling psoriasiform dermatitis

Nijmegen Breakage Syndrome is a disease caused by NBN mutations. Here, we report a novel function of Nbn in skin homeostasis. We found that Nbn deficiency in hair follicle (HF) progenitors promoted increased DNA damage signaling, stimulating p16(Ink4a) up-regulation, Trp53 stabilization and cytokine...

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Detalles Bibliográficos
Autores principales: Seidel, Philipp, Remus, Martina, Delacher, Michael, Grigaravicius, Paulius, Reuss, David E., Frappart, Lucien, von Deimling, Andreas, Feuerer, Markus, Abdollahi, Amir, Frappart, Pierre-Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper: Gerotarget (Focus on Aging)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029606/
https://www.ncbi.nlm.nih.gov/pubmed/27050272
http://dx.doi.org/10.18632/oncotarget.8470

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029606/
https://www.ncbi.nlm.nih.gov/pubmed/27050272
http://dx.doi.org/10.18632/oncotarget.8470

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