Circadian factors BMAL1 and RORα control HIF-1α transcriptional activity in nucleus pulposus cells: implications in maintenance of intervertebral disc health

BMAL1 and RORα are major regulators of the circadian molecular oscillator. Since previous work in other cell types has shown cross talk between circadian rhythm genes and hypoxic signaling, we investigated the role of BMAL1 and RORα in controlling HIF-1-dependent transcriptional responses in NP cell...

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Detalles Bibliográficos
Autores principales: Suyama, Kaori, Silagi, Elizabeth S., Choi, Hyowon, Sakabe, Kou, Mochida, Joji, Shapiro, Irving M., Risbud, Makarand V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper: Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029610/
https://www.ncbi.nlm.nih.gov/pubmed/27049729
http://dx.doi.org/10.18632/oncotarget.8521

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029610/
https://www.ncbi.nlm.nih.gov/pubmed/27049729
http://dx.doi.org/10.18632/oncotarget.8521

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