Cargando…

Circadian factors BMAL1 and RORα control HIF-1α transcriptional activity in nucleus pulposus cells: implications in maintenance of intervertebral disc health

BMAL1 and RORα are major regulators of the circadian molecular oscillator. Since previous work in other cell types has shown cross talk between circadian rhythm genes and hypoxic signaling, we investigated the role of BMAL1 and RORα in controlling HIF-1-dependent transcriptional responses in NP cell...

Descripción completa

Detalles Bibliográficos
Autores principales:	Suyama, Kaori, Silagi, Elizabeth S., Choi, Hyowon, Sakabe, Kou, Mochida, Joji, Shapiro, Irving M., Risbud, Makarand V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper: Pathology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029610/ https://www.ncbi.nlm.nih.gov/pubmed/27049729 http://dx.doi.org/10.18632/oncotarget.8521

Ejemplares similares

GLUT1 is redundant in hypoxic and glycolytic nucleus pulposus cells of the intervertebral disc
por: Johnston, Shira N., et al.
Publicado: (2023)

Loss of HIF-1α in the Notochord Results in Cell Death and Complete Disappearance of the Nucleus Pulposus
por: Merceron, Christophe, et al.
Publicado: (2014)

Expression of Carbonic Anhydrase III, a Nucleus Pulposus Phenotypic Marker, is Hypoxia-responsive and Confers Protection from Oxidative Stress-induced Cell Death
por: Silagi, Elizabeth S., et al.
Publicado: (2018)

Nucleus pulposus primary cilia alter their length in response to changes in extracellular osmolarity but do not control TonEBP-mediated osmoregulation
por: Choi, Hyowon, et al.
Publicado: (2019)

Transcriptional profiling of the nucleus pulposus: say yes to notochord
por: Shapiro, Irving M, et al.
Publicado: (2010)

Lack of evidence for involvement of TonEBP and hyperosmotic stimulus in induction of autophagy in the nucleus pulposus
por: Liu, Chao, et al.
Publicado: (2017)

BMP-2 and TGF-β Stimulate Expression of β1,3-Glucuronosyl Transferase 1 (GlcAT-1) in Nucleus Pulposus Cells Through AP1, TonEBP, and Sp1: Role of MAPKs
por: Hiyama, Akihiko, et al.
Publicado: (2010)

Aquaporin 1 and 5 expression decreases during human intervertebral disc degeneration: novel HIF-1-mediated regulation of aquaporins in NP cells
por: Johnson, Zariel I., et al.
Publicado: (2015)

Transgenic mice overexpressing human TNF-α experience early onset spontaneous intervertebral disc herniation in the absence of overt degeneration
por: Gorth, Deborah J., et al.
Publicado: (2018)

Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc
por: Sakai, Daisuke, et al.
Publicado: (2012)

HIF-1α, HIF-2α, and ProExC: diagnostic or prognostic relevance in conjunctival intraepithelial neoplasia?
por: Nuessle, Simone, et al.
Publicado: (2020)

Effects of interleukin‐17A in nucleus pulposus cells and its small‐molecule inhibitors for intervertebral disc disease
por: Suyama, Kaori, et al.
Publicado: (2018)

Extracellular osmolarity regulates matrix homeostasis in the intervertebral disc and articular cartilage: Evolving role of TonEBP
por: Johnson, Zariel I., et al.
Publicado: (2014)

A complex interaction between Wnt signaling and TNF-α in nucleus pulposus cells
por: Hiyama, Akihiko, et al.
Publicado: (2013)

The mitophagy receptor BNIP3 is critical for the regulation of metabolic homeostasis and mitochondrial function in the nucleus pulposus cells of the intervertebral disc
por: Madhu, Vedavathi, et al.
Publicado: (2023)

GRP78 Suppresses Lipid Peroxidation and Promotes Cellular Antioxidant Levels in Glial Cells following Hydrogen Peroxide Exposure
por: Suyama, Kaori, et al.
Publicado: (2014)

Circadian clock components RORα and Bmal1 mediate the anti-proliferative effect of MLN4924 in osteosarcoma cells
por: Zhang, Shuju, et al.
Publicado: (2016)

The role of hypoxic-inducible factor (HIF1α) and aldolaseC protein in endometrial carcinogenesis: a retrospective study of 279 patients
por: Mhawech-Fauceglia, Paulette, et al.
Publicado: (2012)

Bavachalcone Enhances RORα Expression, Controls Bmal1 Circadian Transcription, and Depresses Cellular Senescence in Human Endothelial Cells
por: Dang, Yanqi, et al.
Publicado: (2015)

Effect of Cryopreservation on Canine and Human Activated Nucleus Pulposus Cells: A Feasibility Study for Cell Therapy of the Intervertebral Disc
por: Tanaka, Masahiro, et al.
Publicado: (2013)

Abcc6 Null Mice—a Model for Mineralization Disorder PXE Shows Vertebral Osteopenia Without Enhanced Intervertebral Disc Calcification With Aging
por: Boneski, Paige K., et al.
Publicado: (2022)

Alterations in ECM signature underscore multiple sub-phenotypes of intervertebral disc degeneration
por: Ohnishi, Takashi, et al.
Publicado: (2020)

Copper activates HIF-1α/GPER/VEGF signalling in cancer cells
por: Rigiracciolo, Damiano Cosimo, et al.
Publicado: (2015)

N-cadherin is Key to Expression of the Nucleus Pulposus Cell Phenotype under Selective Substrate Culture Conditions
por: Hwang, Priscilla Y, et al.
Publicado: (2016)

An organ culture system to model early degenerative changes of the intervertebral disc
por: Ponnappan, Ravi K, et al.
Publicado: (2011)

Editorial: Intervertebral disc degeneration and osteoarthritis: mechanisms of disease and functional repair
por: Teixeira, Graciosa Q., et al.
Publicado: (2023)

Overexpression of hypoxia-inducible-factor 1α(HIF-1α) in oesophageal squamous cell carcinoma correlates with lymph node metastasis and pathologic stage
por: Kurokawa, T, et al.
Publicado: (2003)

Rorα is essential for nuocyte development
por: Wong, See Heng, et al.
Publicado: (2012)

Comparison of inbred mouse strains shows diverse phenotypic outcomes of intervertebral disc aging
por: Novais, Emanuel J., et al.
Publicado: (2020)

An organ culture system to model early degenerative changes of the intervertebral disc II: profiling global gene expression changes
por: Markova, Dessislava Z, et al.
Publicado: (2013)

Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice
por: Novais, Emanuel J., et al.
Publicado: (2021)

Detection of α-defensin in eosinophils in helminth-infected mouse model
por: KHATUN, Afia, et al.
Publicado: (2018)

RORα and RORγ expression inversely correlates with human melanoma progression
por: Brożyna, Anna A., et al.
Publicado: (2016)

RORγt and RORα signature genes in human Th17 cells
por: Castro, Glenda, et al.
Publicado: (2017)

Pparα knockout in mice increases the Th17 development by facilitating the IKKα/RORγt and IKKα/Foxp3 complexes
por: Wei, Ping, et al.
Publicado: (2023)

The potential role and trend of HIF-1α in intervertebral disc degeneration: Friend or foe?
por: Li, Yongjin, et al.
Publicado: (2021)

Urolithin A Inhibits the Catabolic Effect of TNFα on Nucleus Pulposus Cell and Alleviates Intervertebral Disc Degeneration in vivo
por: Liu, Huiyong, et al.
Publicado: (2018)

Mycobacterial infection induces eosinophilia and production of α-defensin by eosinophils in mice
por: KHATUN, Afia, et al.
Publicado: (2018)

The cGAS-STING Pathway Affects Vertebral Bone but Does Not Promote Intervertebral Disc Cell Senescence or Degeneration
por: Ottone, Olivia K., et al.
Publicado: (2022)

Elevated expression of HIF-lα in actively growing prostate tissues is associated with clinical features of benign prostatic hyperplasia
por: Wu, Fei, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_17qdhqjkq6ck60vbhofmsuiiic