BAY 11-7085 induces glucocorticoid receptor activation and autophagy that collaborate with apoptosis to induce human synovial fibroblast cell death

Inhibition of proapoptotic pathways in synovial fibroblasts is one of the major causes of synovial proliferation and hyperplasia in rheumatic diseases. We have shown previously that NF-κB inhibitor BAY 11-7085, through inactivation of PPAR-γ, induces apoptosis in human synovial fibroblasts. In this...

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Detalles Bibliográficos
Autores principales: Relic, Biserka, Charlier, Edith, Deroyer, Celine, Malaise, Olivier, Neuville, Sophie, Desoroux, Aline, Gillet, Philippe, de Seny, Dominique, Malaise, Michel G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029633/
https://www.ncbi.nlm.nih.gov/pubmed/26993765
http://dx.doi.org/10.18632/oncotarget.8042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029633/
https://www.ncbi.nlm.nih.gov/pubmed/26993765
http://dx.doi.org/10.18632/oncotarget.8042

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