Cargando…

BAY 11-7085 induces glucocorticoid receptor activation and autophagy that collaborate with apoptosis to induce human synovial fibroblast cell death

Inhibition of proapoptotic pathways in synovial fibroblasts is one of the major causes of synovial proliferation and hyperplasia in rheumatic diseases. We have shown previously that NF-κB inhibitor BAY 11-7085, through inactivation of PPAR-γ, induces apoptosis in human synovial fibroblasts. In this...

Descripción completa

Detalles Bibliográficos
Autores principales:	Relic, Biserka, Charlier, Edith, Deroyer, Celine, Malaise, Olivier, Neuville, Sophie, Desoroux, Aline, Gillet, Philippe, de Seny, Dominique, Malaise, Michel G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029633/ https://www.ncbi.nlm.nih.gov/pubmed/26993765 http://dx.doi.org/10.18632/oncotarget.8042

Ejemplares similares

Serum starvation raises turnover of phosphorylated p62/SQSTM1 (Serine 349), reveals expression of proteasome and N-glycanase1 interactive protein RAD23B and sensitizes human synovial fibroblasts to BAY 11-7085-induced cell death
por: Relic, Biserka, et al.
Publicado: (2018)

Glucocorticoid-induced leucine zipper (GILZ) is involved in glucocorticoid-induced and mineralocorticoid-induced leptin production by osteoarthritis synovial fibroblasts
por: Malaise, Olivier, et al.
Publicado: (2016)

TFEB phosphorylation on Serine 211 is induced by autophagy in human synovial fibroblasts and by p62/SQSTM1 overexpression in HEK293 cells
por: Relic, Biserka, et al.
Publicado: (2021)

Insights on Molecular Mechanisms of Chondrocytes Death in Osteoarthritis
por: Charlier, Edith, et al.
Publicado: (2016)

CEMIP (KIAA1199) induces a fibrosis-like process in osteoarthritic chondrocytes
por: Deroyer, Céline, et al.
Publicado: (2019)

Acute-Phase Serum Amyloid A in Osteoarthritis: Regulatory Mechanism and Proinflammatory Properties
por: de Seny, Dominique, et al.
Publicado: (2013)

Influence of Glucocorticoids on Cellular Senescence Hallmarks in Osteoarthritic Fibroblast-like Synoviocytes
por: Malaise, Olivier, et al.
Publicado: (2021)

Apolipoprotein-A1 as a Damage-Associated Molecular Patterns Protein in Osteoarthritis: Ex Vivo and In Vitro Pro-Inflammatory Properties
por: de Seny, Dominique, et al.
Publicado: (2015)

Toward diagnostic relevance of the α(V)β(5), α(V)β(3), and α(V)β(6) integrins in OA: expression within human cartilage and spinal osteophytes
por: Charlier, Edith, et al.
Publicado: (2020)

CEMIP (KIAA1199) regulates inflammation, hyperplasia and fibrosis in osteoarthritis synovial membrane
por: Deroyer, Céline, et al.
Publicado: (2022)

Modulation of α(V)β(6) integrin in osteoarthritis-related synovitis and the interaction with VTN((381–397 a.a.)) competing for TGF-β1 activation
por: Ciregia, Federica, et al.
Publicado: (2021)

New Proteins Contributing to Immune Cell Infiltration and Pannus Formation of Synovial Membrane from Arthritis Diseases
por: de Seny, Dominique, et al.
Publicado: (2021)

Repurposing Kinase Inhibitor Bay 11-7085 to Combat Staphylococcus aureus and Candida albicans Biofilms
por: Escobar, Iliana E., et al.
Publicado: (2021)

Inflammatory profile of induced sputum composition in systemic sclerosis and comparison with healthy volunteers
por: Jacquerie, P., et al.
Publicado: (2021)

Effect of Grain Structure and Quenching Rate on the Susceptibility to Exfoliation Corrosion in 7085 Alloy
por: Cao, Puli, et al.
Publicado: (2023)

(18)F- FDG PET/CT joint assessment of early therapeutic response in rheumatoid arthritis patients treated with rituximab
por: FOSSE, Pacôme, et al.
Publicado: (2018)

Ultrasonic Bending Vibration-Assisted Purification Experimental Study of 7085 Aluminum Alloy Melt
por: Shi, Chen, et al.
Publicado: (2022)

POL7085 or anti‐CCL28 treatment inhibits development of post‐paramyxoviral airway disease
por: Buelow, Becky J., et al.
Publicado: (2017)

Corrosion Behavior and Mechanical Performance of 7085 Aluminum Alloy in a Humid and Hot Marine Atmosphere
por: Tao, Jianquan, et al.
Publicado: (2022)

Biomarkers in systemic sclerosis-associated interstitial lung disease: review of the literature
por: Bonhomme, Olivier, et al.
Publicado: (2019)

Psychological interventions influence patients' attitudes and beliefs about their chronic pain
por: Vanhaudenhuyse, Audrey, et al.
Publicado: (2017)

High detection rate of osteoporosis with screening of a general hospitalized population: a 6-year study in 6406 patients in a university hospital setting
por: Malaise, Olivier, et al.
Publicado: (2020)

Challenges for Biomarker Discovery in Body Fluids Using SELDI-TOF-MS
por: De Bock, Muriel, et al.
Publicado: (2010)

Biomarkers of inflammation and innate immunity in atrophic nonunion fracture
por: de Seny, Dominique, et al.
Publicado: (2016)

Serum IGFBP-2 in systemic sclerosis as a prognostic factor of lung dysfunction
por: Guiot, Julien, et al.
Publicado: (2021)

Reproducibility of pulmonary function tests in patients with systemic sclerosis
por: Jacquerie, P., et al.
Publicado: (2023)

Lung Function Impairment, Associating Hyperinflation with Impaired Diffusion Capacity and Transfer Coefficient, Is a Risk Factor for Hip Osteoporosis in Patients with Chronic Obstructive Pulmonary Disease
por: Malaise, Olivier, et al.
Publicado: (2023)

Protective effect of a Protein Epitope Mimetic CCR10 antagonist, POL7085, in a model of allergic eosinophilic airway inflammation
por: Daubeuf, François, et al.
Publicado: (2015)

Dissociation between 2-[(18)F]fluoro-2-deoxy-D-glucose positron emission computed tomography, ultrasound and clinical assessments in patients with non-severe rheumatoid arthritis, including remission
por: Rinkin, Charline, et al.
Publicado: (2021)

A Cross-Sectional and Longitudinal Study to Define Alarmins and A-SAA Variants as Companion Markers in Early Rheumatoid Arthritis
por: Ciregia, Federica, et al.
Publicado: (2021)

Proteins involved in the endoplasmic reticulum stress are modulated in synovitis of osteoarthritis, chronic pyrophosphate arthropathy and rheumatoid arthritis, and correlate with the histological inflammatory score
por: de Seny, Dominique, et al.
Publicado: (2020)

Progressive fibrosing interstitial lung disease in rheumatoid arthritis: A retrospective study
por: Denis, Anna, et al.
Publicado: (2022)

Glycosylation deficiency of lipopolysaccharide-binding protein and corticosteroid-binding globulin associated with activity and response to treatment for rheumatoid arthritis
por: Ciregia, Federica, et al.
Publicado: (2020)

Orthovoltage X-ray Minibeam Radiation Therapy for the Treatment of Ocular Tumours—An In Silico Evaluation
por: Schneider, Tim, et al.
Publicado: (2023)

Blood lymphocyte subsets after the first fraction in patients given hyperfractionated total body irradiation for bone marrow transplantation.
por: Girinsky, T., et al.
Publicado: (1991)

Optimal Deep Stacked Sparse Autoencoder Based Osteosarcoma Detection and Classification Model
por: Fakieh, Bahjat, et al.
Publicado: (2022)

Artificial Intelligence Based COVID-19 Detection and Classification Model on Chest X-ray Images
por: Althaqafi, Turki, et al.
Publicado: (2023)

Local administration of glucocorticoids decreases synovial citrullination in rheumatoid arthritis
por: Makrygiannakis, Dimitrios, et al.
Publicado: (2012)

ScaleUp: middleware for intelligent environments
por: Alghazzawi, Daniyal, et al.
Publicado: (2021)

Exosomes from Human Synovial-Derived Mesenchymal Stem Cells Prevent Glucocorticoid-Induced Osteonecrosis of the Femoral Head in the Rat
por: Guo, Shang-Chun, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_1arjn2k8ucki9cdads86fenl3v