Activation of autophagy flux by metformin downregulates cellular FLICE–like inhibitory protein and enhances TRAIL- induced apoptosis

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily. TRAIL is regarded as one of the most promising anticancer agents, because it can destruct cancer cells without showing any toxicity to normal cells. Metformin is an anti-diabetic drug with antic...

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Detalles Bibliográficos
Autores principales: Nazim, Uddin MD, Moon, Ji-Hong, Lee, Ju-Hee, Lee, You-Jin, Seol, Jae-Won, Eo, Seong-Kug, Lee, John-Hwa, Park, Sang-Youel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029640/
https://www.ncbi.nlm.nih.gov/pubmed/26992204
http://dx.doi.org/10.18632/oncotarget.8048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029640/
https://www.ncbi.nlm.nih.gov/pubmed/26992204
http://dx.doi.org/10.18632/oncotarget.8048

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