TKI sensitivity patterns of novel kinase-domain mutations suggest therapeutic opportunities for patients with resistant ALK+ tumors

The anaplastic lymphoma kinase (ALK) protein drives tumorigenesis in subsets of several tumors through chromosomal rearrangements that express and activate its C-terminal kinase domain. In addition, germline predisposition alleles and acquired mutations are found in the full-length protein in the pe...

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Detalles Bibliográficos
Autores principales: Amin, Amit Dipak, Li, Lingxiao, Rajan, Soumya S., Gokhale, Vijay, Groysman, Matthew J., Pongtornpipat, Praechompoo, Tapia, Edgar O., Wang, Mengdie, Schatz, Jonathan H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029658/
https://www.ncbi.nlm.nih.gov/pubmed/27009859
http://dx.doi.org/10.18632/oncotarget.8173

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029658/
https://www.ncbi.nlm.nih.gov/pubmed/27009859
http://dx.doi.org/10.18632/oncotarget.8173

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