Activation of TRPV2 and BKCa channels by the LL-37 enantiomers stimulates calcium entry and migration of cancer cells

Expression of the antimicrobial peptide hCAP18/LL-37 is associated to malignancy in various cancer forms, stimulating cell migration and metastasis. We report that LL-37 induces migration of three cancer cell lines by activating the TRPV2 calcium-permeable channel and recruiting it to pseudopodia th...

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Detalles Bibliográficos
Autores principales: Gambade, Audrey, Zreika, Sami, Guéguinou, Maxime, Chourpa, Igor, Fromont, Gaëlle, Bouchet, Ana Maria, Burlaud-Gaillard, Julien, Potier-Cartereau, Marie, Roger, Sébastien, Aucagne, Vincent, Chevalier, Stéphan, Vandier, Christophe, Goupille, Caroline, Weber, Günther
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029663/
https://www.ncbi.nlm.nih.gov/pubmed/26993604
http://dx.doi.org/10.18632/oncotarget.8122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029663/
https://www.ncbi.nlm.nih.gov/pubmed/26993604
http://dx.doi.org/10.18632/oncotarget.8122

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