Triptolide has anticancer and chemosensitization effects by down-regulating Akt activation through the MDM2/REST pathway in human breast cancer

Triptolide has been shown to exhibit anticancer activity. However, its mechanism of action is not clearly defined. Herein we report a novel signaling pathway, MDM2/Akt, is involved in the anticancer mechanism of triptolide. We observed that triptolide inhibits MDM2 expression in human breast cancer...

Descripción completa

Detalles Bibliográficos
Autores principales: Xiong, Jing, Su, Tiefen, Qu, Zhiling, Yang, Qin, Wang, Yu, Li, Jiansha, Zhou, Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029675/
https://www.ncbi.nlm.nih.gov/pubmed/27004407
http://dx.doi.org/10.18632/oncotarget.8207

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029675/
https://www.ncbi.nlm.nih.gov/pubmed/27004407
http://dx.doi.org/10.18632/oncotarget.8207

Ejemplares similares