An evolutionarily conserved negative feedback mechanism in the Hippo pathway reflects functional difference between LATS1 and LATS2

The Hippo pathway represses YAP oncoprotein activity through phosphorylation by LATS kinases. Although variety of upstream components has been found to participate in the Hippo pathway, the existence and function of negative feedback has remained uncertain. We found that activated YAP, together with...

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Detalles Bibliográficos
Autores principales: Park, Gun-Soo, Oh, Hyangyee, Kim, Minchul, Kim, Tackhoon, Johnson, Randy L., Irvine, Kenneth D., Lim, Dae-Sik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029684/
https://www.ncbi.nlm.nih.gov/pubmed/27006470
http://dx.doi.org/10.18632/oncotarget.8211

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029684/
https://www.ncbi.nlm.nih.gov/pubmed/27006470
http://dx.doi.org/10.18632/oncotarget.8211

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