DEPTOR promotes survival of cervical squamous cell carcinoma cells and its silencing induces apoptosis through downregulating PI3K/AKT and by up-regulating p38 MAP kinase

DEPTOR is an endogenous inhibitor of mTOR complexes, de-regulated in cancers. The present study reveals a vital role for DEPTOR in survival of cervical squamous cell carcinoma (SCC). DEPTOR was found to be overexpressed in both cervical SCC cells and tissues and it's silencing in cervical SCC c...

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Detalles Bibliográficos
Autores principales: Srinivas, Kalanghad Puthankalam, Viji, Remadevi, Dan, Vipin Mohan, Sajitha, Indira Sukumaran, Prakash, Rajappan, Rahul, Puthan Valappil, Santhoshkumar, Thankayyan R., Lakshmi, Subhadra, Pillai, Madhavan Radhakrishna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029691/
https://www.ncbi.nlm.nih.gov/pubmed/26992219
http://dx.doi.org/10.18632/oncotarget.8131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029691/
https://www.ncbi.nlm.nih.gov/pubmed/26992219
http://dx.doi.org/10.18632/oncotarget.8131

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