The retinoblastoma protein regulates hypoxia-inducible genetic programs, tumor cell invasiveness and neuroendocrine differentiation in prostate cancer cells

Loss of tumor suppressor proteins, such as the retinoblastoma protein (Rb), results in tumor progression and metastasis. Metastasis is facilitated by low oxygen availability within the tumor that is detected by hypoxia inducible factors (HIFs). The HIF1 complex, HIF1α and dimerization partner the ar...

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Detalles Bibliográficos
Autores principales: Labrecque, Mark P., Takhar, Mandeep K., Nason, Rebecca, Santacruz, Stephanie, Tam, Kevin J., Massah, Shabnam, Haegert, Anne, Bell, Robert H., Altamirano-Dimas, Manuel, Collins, Colin C., Lee, Frank J.S., Prefontaine, Gratien G., Cox, Michael E., Beischlag, Timothy V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029701/
https://www.ncbi.nlm.nih.gov/pubmed/27015368
http://dx.doi.org/10.18632/oncotarget.8301

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029701/
https://www.ncbi.nlm.nih.gov/pubmed/27015368
http://dx.doi.org/10.18632/oncotarget.8301

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