Multilevel induction of apoptosis by microtubule-interfering inhibitors 4β-S-aromatic heterocyclic podophyllum derivatives causing multi-fold mitochondrial depolarization and PKA signaling pathways in HeLa cells

Herein is a first effort to study effect of carbon-sulfur (C-S) and carbon-nitrogen (C-N) bonds modification on the antitumor activity of the podophyllum derivatives in HeLa cells. Compared with the derivative modified by the C-N bond, the C-S bond modification exhibited superior antitumor activity...

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Detalles Bibliográficos
Autores principales: Zhang, Ya-Xuan, Zhao, Wei, Tang, Ya-Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029702/
https://www.ncbi.nlm.nih.gov/pubmed/27007151
http://dx.doi.org/10.18632/oncotarget.8147

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029702/
https://www.ncbi.nlm.nih.gov/pubmed/27007151
http://dx.doi.org/10.18632/oncotarget.8147

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