Progerin impairs chromosome maintenance by depleting CENP-F from metaphase kinetochores in Hutchinson-Gilford progeria fibroblasts

Hutchinson-Gilford progeria syndrome (HGPS, OMIM 176670) is a rare premature aging disorder that leads to death at an average age of 14.7 years due to myocardial infarction or stroke. The most common mutation in HGPS is at position G608G (GGC>GGT) within exon 11 of the LMNA gene. This mutation re...

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Detalles Bibliográficos
Autores principales: Eisch, Veronika, Lu, Xiang, Gabriel, Diana, Djabali, Karima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029735/
https://www.ncbi.nlm.nih.gov/pubmed/27015553
http://dx.doi.org/10.18632/oncotarget.8267

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029735/
https://www.ncbi.nlm.nih.gov/pubmed/27015553
http://dx.doi.org/10.18632/oncotarget.8267

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