Induced conformational change in human IL‐4 upon binding of a signal‐neutralizing DARPin

The crystal structure of DARPin 44C12V5 that neutralizes IL‐4 signaling has been determined alone and bound to human IL‐4. A significant conformational change occurs in the IL‐4 upon DARPin binding. The DARPin binds to the face of IL‐4 formed by the A and C α‐helices. The structure of the DARPin rem...

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Detalles Bibliográficos
Autores principales: Obmolova, Galina, Teplyakov, Alexey, Malia, Thomas J., Keough, Edward, Luo, Jinquan, Sweet, Raymond, Jacobs, Steven A., Yi, Fang, Hippensteel, Randi, O'Neil, Karyn T., Gilliland, Gary L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Structure Notes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029753/
https://www.ncbi.nlm.nih.gov/pubmed/25900776
http://dx.doi.org/10.1002/prot.24815

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029753/
https://www.ncbi.nlm.nih.gov/pubmed/25900776
http://dx.doi.org/10.1002/prot.24815

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