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Induced conformational change in human IL‐4 upon binding of a signal‐neutralizing DARPin
The crystal structure of DARPin 44C12V5 that neutralizes IL‐4 signaling has been determined alone and bound to human IL‐4. A significant conformational change occurs in the IL‐4 upon DARPin binding. The DARPin binds to the face of IL‐4 formed by the A and C α‐helices. The structure of the DARPin rem...
Autores principales: | Obmolova, Galina, Teplyakov, Alexey, Malia, Thomas J., Keough, Edward, Luo, Jinquan, Sweet, Raymond, Jacobs, Steven A., Yi, Fang, Hippensteel, Randi, O'Neil, Karyn T., Gilliland, Gary L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029753/ https://www.ncbi.nlm.nih.gov/pubmed/25900776 http://dx.doi.org/10.1002/prot.24815 |
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