Diverse fates of uracilated HIV-1 DNA during infection of myeloid lineage cells

We report that a major subpopulation of monocyte-derived macrophages (MDMs) contains high levels of dUTP, which is incorporated into HIV-1 DNA during reverse transcription (U/A pairs), resulting in pre-integration restriction and post-integration mutagenesis. After entering the nucleus, uracilated v...

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Detalles Bibliográficos
Autores principales: Hansen, Erik C, Ransom, Monica, Hesselberth, Jay R, Hosmane, Nina N, Capoferri, Adam A, Bruner, Katherine M, Pollack, Ross A, Zhang, Hao, Drummond, Michael Bradley, Siliciano, Janet M, Siliciano, Robert, Stivers, James T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030084/
https://www.ncbi.nlm.nih.gov/pubmed/27644592
http://dx.doi.org/10.7554/eLife.18447

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030084/
https://www.ncbi.nlm.nih.gov/pubmed/27644592
http://dx.doi.org/10.7554/eLife.18447

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