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Allosteric activation of SENP1 by SUMO1 β-grasp domain involves a dock-and-coalesce mechanism
Small ubiquitin-related modifiers (SUMOs) are conjugated to proteins to regulate a variety of cellular processes. SENPs are cysteine proteases with a catalytic center located within a channel between two subdomains that catalyzes SUMO C-terminal cleavage for processing of SUMO precursors and de-SUMO...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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eLife Sciences Publications, Ltd
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030089/ https://www.ncbi.nlm.nih.gov/pubmed/27576863 http://dx.doi.org/10.7554/eLife.18249 |