ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer

The androgen receptor (AR) is overexpressed and hyperactivated in human castration-resistant prostate cancer (CRPC). However, the determinants of AR overexpression in CRPC are poorly defined. Here we show that retinoid acid receptor-related orphan receptor γ (ROR-γ) is overexpressed and amplified in...

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Detalles Bibliográficos
Autores principales: Wang, Junjian, Zou, June X., Xue, Xiaoqian, Cai, Demin, Zhang, Yan, Duan, Zhijian, Xiang, Qiuping, Yang, Joy C., Louie, Maggie C., Borowsky, Alexander D., Gao, Allen C., Evans, Christopher P., Lam, Kit S., Xu, Jianzhen, Kung, Hsing-Jien, Evans, Ronald M., Xu, Yong, Chen, Hong-Wu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030109/
https://www.ncbi.nlm.nih.gov/pubmed/27019329
http://dx.doi.org/10.1038/nm.4070

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030109/
https://www.ncbi.nlm.nih.gov/pubmed/27019329
http://dx.doi.org/10.1038/nm.4070

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