Dual Action Antifungal Small Molecule Modulates Multidrug Efflux and TOR Signaling

There is an urgent need for new strategies to treat invasive fungal infections, which are a leading cause of human mortality. We establish two activities of the natural product beauvericin, which potentiates the activity of the most widely deployed class of antifungal against the leading human funga...

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Detalles Bibliográficos
Autores principales: Shekhar-Guturja, Tanvi, Gunaherath, G. M. Kamal B., Kithsiri Wijeratne, E. M., Lambert, Jean-Philippe, Averette, Anna F., Lee, Soo Chan, Kim, Taeyup, Bahn, Yong-Sun, Tripodi, Farida, Ammar, Ron, Döhl, Katja, Niewola-Staszkowska, Karolina, Schmitt, Lutz, Loewith, Robbie J., Roth, Frederick P., Sanglard, Dominique, Andes, David, Nislow, Corey, Coccetti, Paola, Gingras, Anne-Claude, Heitman, Joseph, Leslie Gunatilaka, A. A., Cowen, Leah E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030160/
https://www.ncbi.nlm.nih.gov/pubmed/27571477
http://dx.doi.org/10.1038/nchembio.2165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030160/
https://www.ncbi.nlm.nih.gov/pubmed/27571477
http://dx.doi.org/10.1038/nchembio.2165

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