Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin

Colibactin represents an as-yet uncharacterized genotoxic secondary metabolite produced by human gut bacteria. Here we report the biosynthetic discovery of two new precolibactin molecules from Escherichia coli, including precolibactin-886 that uniquely incorporates the highly sought genotoxicity-ass...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Zhong-Rui, Li, Jie, Gu, Jin-Ping, Lai, Jennifer Y. H., Duggan, Brendan M., Zhang, Wei-Peng, Li, Zhi-Long, Li, Yong-Xin, Tong, Rong-Biao, Xu, Ying, Lin, Dong-Hai, Moore, Bradley S., Qian, Pei-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030165/
https://www.ncbi.nlm.nih.gov/pubmed/27547923
http://dx.doi.org/10.1038/nchembio.2157

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030165/
https://www.ncbi.nlm.nih.gov/pubmed/27547923
http://dx.doi.org/10.1038/nchembio.2157

Ejemplares similares