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Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin
Colibactin represents an as-yet uncharacterized genotoxic secondary metabolite produced by human gut bacteria. Here we report the biosynthetic discovery of two new precolibactin molecules from Escherichia coli, including precolibactin-886 that uniquely incorporates the highly sought genotoxicity-ass...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030165/ https://www.ncbi.nlm.nih.gov/pubmed/27547923 http://dx.doi.org/10.1038/nchembio.2157 |
| _version_ | 1782454629942951936 |
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| author | Li, Zhong-Rui Li, Jie Gu, Jin-Ping Lai, Jennifer Y. H. Duggan, Brendan M. Zhang, Wei-Peng Li, Zhi-Long Li, Yong-Xin Tong, Rong-Biao Xu, Ying Lin, Dong-Hai Moore, Bradley S. Qian, Pei-Yuan |
| author_facet | Li, Zhong-Rui Li, Jie Gu, Jin-Ping Lai, Jennifer Y. H. Duggan, Brendan M. Zhang, Wei-Peng Li, Zhi-Long Li, Yong-Xin Tong, Rong-Biao Xu, Ying Lin, Dong-Hai Moore, Bradley S. Qian, Pei-Yuan |
| author_sort | Li, Zhong-Rui |
| collection | PubMed |
| description | Colibactin represents an as-yet uncharacterized genotoxic secondary metabolite produced by human gut bacteria. Here we report the biosynthetic discovery of two new precolibactin molecules from Escherichia coli, including precolibactin-886 that uniquely incorporates the highly sought genotoxicity-associated aminomalonate building block in its unprecedented macrocyclic structure. This work provides new insights into the biosynthetic logic and mode of action of this colorectal cancer-linked microbial chemical. |
| format | Online Article Text |
| id | pubmed-5030165 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2016 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-50301652017-02-22 Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin Li, Zhong-Rui Li, Jie Gu, Jin-Ping Lai, Jennifer Y. H. Duggan, Brendan M. Zhang, Wei-Peng Li, Zhi-Long Li, Yong-Xin Tong, Rong-Biao Xu, Ying Lin, Dong-Hai Moore, Bradley S. Qian, Pei-Yuan Nat Chem Biol Article Colibactin represents an as-yet uncharacterized genotoxic secondary metabolite produced by human gut bacteria. Here we report the biosynthetic discovery of two new precolibactin molecules from Escherichia coli, including precolibactin-886 that uniquely incorporates the highly sought genotoxicity-associated aminomalonate building block in its unprecedented macrocyclic structure. This work provides new insights into the biosynthetic logic and mode of action of this colorectal cancer-linked microbial chemical. 2016-08-22 2016-10 /pmc/articles/PMC5030165/ /pubmed/27547923 http://dx.doi.org/10.1038/nchembio.2157 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Li, Zhong-Rui Li, Jie Gu, Jin-Ping Lai, Jennifer Y. H. Duggan, Brendan M. Zhang, Wei-Peng Li, Zhi-Long Li, Yong-Xin Tong, Rong-Biao Xu, Ying Lin, Dong-Hai Moore, Bradley S. Qian, Pei-Yuan Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin |
| title | Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin |
| title_full | Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin |
| title_fullStr | Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin |
| title_full_unstemmed | Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin |
| title_short | Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin |
| title_sort | divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030165/ https://www.ncbi.nlm.nih.gov/pubmed/27547923 http://dx.doi.org/10.1038/nchembio.2157 |
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