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Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin

Colibactin represents an as-yet uncharacterized genotoxic secondary metabolite produced by human gut bacteria. Here we report the biosynthetic discovery of two new precolibactin molecules from Escherichia coli, including precolibactin-886 that uniquely incorporates the highly sought genotoxicity-ass...

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Detalles Bibliográficos
Autores principales:	Li, Zhong-Rui, Li, Jie, Gu, Jin-Ping, Lai, Jennifer Y. H., Duggan, Brendan M., Zhang, Wei-Peng, Li, Zhi-Long, Li, Yong-Xin, Tong, Rong-Biao, Xu, Ying, Lin, Dong-Hai, Moore, Bradley S., Qian, Pei-Yuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030165/ https://www.ncbi.nlm.nih.gov/pubmed/27547923 http://dx.doi.org/10.1038/nchembio.2157

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