RNAs Containing Modified Nucleotides Fail To Trigger RIG-I Conformational Changes for Innate Immune Signaling

Invading pathogen nucleic acids are recognized and bound by cytoplasmic (retinoic acid-inducible gene I [RIG-I]-like) and membrane-bound (Toll-like) pattern recognition receptors to activate innate immune signaling. Modified nucleotides, when present in RNA molecules, diminish the magnitude of these...

Descripción completa

Detalles Bibliográficos
Autores principales: Durbin, Ann Fiegen, Wang, Chen, Marcotrigiano, Joseph, Gehrke, Lee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030355/
https://www.ncbi.nlm.nih.gov/pubmed/27651356
http://dx.doi.org/10.1128/mBio.00833-16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030355/
https://www.ncbi.nlm.nih.gov/pubmed/27651356
http://dx.doi.org/10.1128/mBio.00833-16

Ejemplares similares