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RNAs Containing Modified Nucleotides Fail To Trigger RIG-I Conformational Changes for Innate Immune Signaling

Invading pathogen nucleic acids are recognized and bound by cytoplasmic (retinoic acid-inducible gene I [RIG-I]-like) and membrane-bound (Toll-like) pattern recognition receptors to activate innate immune signaling. Modified nucleotides, when present in RNA molecules, diminish the magnitude of these...

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Detalles Bibliográficos
Autores principales:	Durbin, Ann Fiegen, Wang, Chen, Marcotrigiano, Joseph, Gehrke, Lee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030355/ https://www.ncbi.nlm.nih.gov/pubmed/27651356 http://dx.doi.org/10.1128/mBio.00833-16

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