A Facile Electrochemical Preparation of Reduced Graphene Oxide@Polydopamine Composite: A Novel Electrochemical Sensing Platform for Amperometric Detection of Chlorpromazine
We report a novel and sensitive amperometric sensor for chlorpromazine (CPZ) based on reduced graphene oxide (RGO) and polydopamine (PDA) composite modified glassy carbon electrode. The RGO@PDA composite was prepared by electrochemical reduction of graphene oxide (GO) with PDA. The RGO@PDA composite...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030524/ https://www.ncbi.nlm.nih.gov/pubmed/27650697 http://dx.doi.org/10.1038/srep33599 |
_version_ | 1782454695080493056 |
---|---|
author | Palanisamy, Selvakumar Thirumalraj, Balamurugan Chen, Shen-Ming Wang, Yi-Ting Velusamy, Vijayalakshmi Ramaraj, Sayee Kannan |
author_facet | Palanisamy, Selvakumar Thirumalraj, Balamurugan Chen, Shen-Ming Wang, Yi-Ting Velusamy, Vijayalakshmi Ramaraj, Sayee Kannan |
author_sort | Palanisamy, Selvakumar |
collection | PubMed |
description | We report a novel and sensitive amperometric sensor for chlorpromazine (CPZ) based on reduced graphene oxide (RGO) and polydopamine (PDA) composite modified glassy carbon electrode. The RGO@PDA composite was prepared by electrochemical reduction of graphene oxide (GO) with PDA. The RGO@PDA composite modified electrode shows an excellent electro-oxidation behavior to CPZ when compared with other modified electrodes such as GO, RGO and GO@PDA. Amperometric i-t method was used for the determination of CPZ. Amperometry result shows that the RGO@PDA composite detects CPZ in a linear range from 0.03 to 967.6 μM. The sensor exhibits a low detection limit of 0.0018 μM with the analytical sensitivity of 3.63 ± 0.3 μAμM(–1 )cm(–2). The RGO@PDA composite shows its high selectivity towards CPZ in the presence of potentially interfering drugs such as metronidazole, phenobarbital, chlorpheniramine maleate, pyridoxine and riboflavin. In addition, the fabricated RGO@PDA modified electrode showed an appropriate recovery towards CPZ in the pharmaceutical tablets. |
format | Online Article Text |
id | pubmed-5030524 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-50305242016-09-26 A Facile Electrochemical Preparation of Reduced Graphene Oxide@Polydopamine Composite: A Novel Electrochemical Sensing Platform for Amperometric Detection of Chlorpromazine Palanisamy, Selvakumar Thirumalraj, Balamurugan Chen, Shen-Ming Wang, Yi-Ting Velusamy, Vijayalakshmi Ramaraj, Sayee Kannan Sci Rep Article We report a novel and sensitive amperometric sensor for chlorpromazine (CPZ) based on reduced graphene oxide (RGO) and polydopamine (PDA) composite modified glassy carbon electrode. The RGO@PDA composite was prepared by electrochemical reduction of graphene oxide (GO) with PDA. The RGO@PDA composite modified electrode shows an excellent electro-oxidation behavior to CPZ when compared with other modified electrodes such as GO, RGO and GO@PDA. Amperometric i-t method was used for the determination of CPZ. Amperometry result shows that the RGO@PDA composite detects CPZ in a linear range from 0.03 to 967.6 μM. The sensor exhibits a low detection limit of 0.0018 μM with the analytical sensitivity of 3.63 ± 0.3 μAμM(–1 )cm(–2). The RGO@PDA composite shows its high selectivity towards CPZ in the presence of potentially interfering drugs such as metronidazole, phenobarbital, chlorpheniramine maleate, pyridoxine and riboflavin. In addition, the fabricated RGO@PDA modified electrode showed an appropriate recovery towards CPZ in the pharmaceutical tablets. Nature Publishing Group 2016-09-21 /pmc/articles/PMC5030524/ /pubmed/27650697 http://dx.doi.org/10.1038/srep33599 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Palanisamy, Selvakumar Thirumalraj, Balamurugan Chen, Shen-Ming Wang, Yi-Ting Velusamy, Vijayalakshmi Ramaraj, Sayee Kannan A Facile Electrochemical Preparation of Reduced Graphene Oxide@Polydopamine Composite: A Novel Electrochemical Sensing Platform for Amperometric Detection of Chlorpromazine |
title | A Facile Electrochemical Preparation of Reduced Graphene Oxide@Polydopamine Composite: A Novel Electrochemical Sensing Platform for Amperometric Detection of Chlorpromazine |
title_full | A Facile Electrochemical Preparation of Reduced Graphene Oxide@Polydopamine Composite: A Novel Electrochemical Sensing Platform for Amperometric Detection of Chlorpromazine |
title_fullStr | A Facile Electrochemical Preparation of Reduced Graphene Oxide@Polydopamine Composite: A Novel Electrochemical Sensing Platform for Amperometric Detection of Chlorpromazine |
title_full_unstemmed | A Facile Electrochemical Preparation of Reduced Graphene Oxide@Polydopamine Composite: A Novel Electrochemical Sensing Platform for Amperometric Detection of Chlorpromazine |
title_short | A Facile Electrochemical Preparation of Reduced Graphene Oxide@Polydopamine Composite: A Novel Electrochemical Sensing Platform for Amperometric Detection of Chlorpromazine |
title_sort | facile electrochemical preparation of reduced graphene oxide@polydopamine composite: a novel electrochemical sensing platform for amperometric detection of chlorpromazine |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030524/ https://www.ncbi.nlm.nih.gov/pubmed/27650697 http://dx.doi.org/10.1038/srep33599 |
work_keys_str_mv | AT palanisamyselvakumar afacileelectrochemicalpreparationofreducedgrapheneoxidepolydopaminecompositeanovelelectrochemicalsensingplatformforamperometricdetectionofchlorpromazine AT thirumalrajbalamurugan afacileelectrochemicalpreparationofreducedgrapheneoxidepolydopaminecompositeanovelelectrochemicalsensingplatformforamperometricdetectionofchlorpromazine AT chenshenming afacileelectrochemicalpreparationofreducedgrapheneoxidepolydopaminecompositeanovelelectrochemicalsensingplatformforamperometricdetectionofchlorpromazine AT wangyiting afacileelectrochemicalpreparationofreducedgrapheneoxidepolydopaminecompositeanovelelectrochemicalsensingplatformforamperometricdetectionofchlorpromazine AT velusamyvijayalakshmi afacileelectrochemicalpreparationofreducedgrapheneoxidepolydopaminecompositeanovelelectrochemicalsensingplatformforamperometricdetectionofchlorpromazine AT ramarajsayeekannan afacileelectrochemicalpreparationofreducedgrapheneoxidepolydopaminecompositeanovelelectrochemicalsensingplatformforamperometricdetectionofchlorpromazine AT palanisamyselvakumar facileelectrochemicalpreparationofreducedgrapheneoxidepolydopaminecompositeanovelelectrochemicalsensingplatformforamperometricdetectionofchlorpromazine AT thirumalrajbalamurugan facileelectrochemicalpreparationofreducedgrapheneoxidepolydopaminecompositeanovelelectrochemicalsensingplatformforamperometricdetectionofchlorpromazine AT chenshenming facileelectrochemicalpreparationofreducedgrapheneoxidepolydopaminecompositeanovelelectrochemicalsensingplatformforamperometricdetectionofchlorpromazine AT wangyiting facileelectrochemicalpreparationofreducedgrapheneoxidepolydopaminecompositeanovelelectrochemicalsensingplatformforamperometricdetectionofchlorpromazine AT velusamyvijayalakshmi facileelectrochemicalpreparationofreducedgrapheneoxidepolydopaminecompositeanovelelectrochemicalsensingplatformforamperometricdetectionofchlorpromazine AT ramarajsayeekannan facileelectrochemicalpreparationofreducedgrapheneoxidepolydopaminecompositeanovelelectrochemicalsensingplatformforamperometricdetectionofchlorpromazine |