Quinone derivatives isolated from the endolichenic fungus Phialocephala fortinii are Mdr1 modulators that combat azole resistance in Candida albicans

One of the main azole-resistance mechanisms in Candida pathogens is the upregulation of drug efflux pumps, which compromises the efficacy of azoles and results in treatment failure. The combination of azole-antifungal agents with efflux pump inhibitors represents a promising strategy to combat funga...

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Detalles Bibliográficos
Autores principales: Xie, Fei, Chang, Wenqiang, Zhang, Ming, Li, Ying, Li, Wei, Shi, Hongzhuo, Zheng, Sha, Lou, Hongxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030645/
https://www.ncbi.nlm.nih.gov/pubmed/27650180
http://dx.doi.org/10.1038/srep33687

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030645/
https://www.ncbi.nlm.nih.gov/pubmed/27650180
http://dx.doi.org/10.1038/srep33687

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