RAG-induced DNA lesions activate proapoptotic BIM to suppress lymphomagenesis in p53-deficient mice

Neoplastic transformation is driven by oncogenic lesions that facilitate unrestrained cell expansion and resistance to antiproliferative signals. These oncogenic DNA lesions, acquired through errors in DNA replication, gene recombination, or extrinsically imposed damage, are thought to activate mult...

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Detalles Bibliográficos
Autores principales: Delbridge, Alex R.D., Pang, Swee Heng Milon, Vandenberg, Cassandra J., Grabow, Stephanie, Aubrey, Brandon J., Tai, Lin, Herold, Marco J., Strasser, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030795/
https://www.ncbi.nlm.nih.gov/pubmed/27621418
http://dx.doi.org/10.1084/jem.20150477

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030795/
https://www.ncbi.nlm.nih.gov/pubmed/27621418
http://dx.doi.org/10.1084/jem.20150477

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