Pyroptosis triggers pore-induced intracellular traps (PITs) that capture bacteria and lead to their clearance by efferocytosis

Inflammasomes activate caspase-1 in response to cytosolic contamination or perturbation. This inflammatory caspase triggers the opening of the GSDMD pore in the plasma membrane, resulting in lytic cell death called pyroptosis. We had previously assumed that pyroptosis releases intracellular bacteria...

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Detalles Bibliográficos
Autores principales: Jorgensen, Ine, Zhang, Yue, Krantz, Bryan A., Miao, Edward A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030797/
https://www.ncbi.nlm.nih.gov/pubmed/27573815
http://dx.doi.org/10.1084/jem.20151613

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030797/
https://www.ncbi.nlm.nih.gov/pubmed/27573815
http://dx.doi.org/10.1084/jem.20151613

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