Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection

Lysosomal cathepsins regulate an exquisite range of biological functions, and their deregulation is associated with inflammatory, metabolic, and degenerative diseases in humans. In this study, we identified a key cell-intrinsic role for cathepsin B as a negative feedback regulator of lysosomal bioge...

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Detalles Bibliográficos
Autores principales: Qi, Xiaopeng, Man, Si Ming, Malireddi, R.K. Subbarao, Karki, Rajendra, Lupfer, Christopher, Gurung, Prajwal, Neale, Geoffrey, Guy, Clifford S., Lamkanfi, Mohamed, Kanneganti, Thirumala-Devi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030800/
https://www.ncbi.nlm.nih.gov/pubmed/27551156
http://dx.doi.org/10.1084/jem.20151938

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030800/
https://www.ncbi.nlm.nih.gov/pubmed/27551156
http://dx.doi.org/10.1084/jem.20151938

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